Paulo Dybala is in doubt with a stomach bug and Merih Demiral is the favourite to start in the Juventus defence against Lokomotiv Moscow.
Juan Cuadrado is suspended, so makes way for Danilo, while Matthijs de Ligt joined Giorgio Chiellini on the treatment table with a sprained ankle.
Turkey international Demiral is the favourite to start in his place, ahead of Daniele Rugani, even though it would be the ex-Sassuolo defender’s career debut in the Champions League.
Dybala is struggling with a stomach bug, so Gonzalo Higuain is expected to partner Cristiano Ronaldo upfront, with Aaron Ramsey facing competition from both Federico Bernardeschi and Douglas Costa for the trequartista role.
Douglas Costa played there for Shakhtar Donetsk, but he too is not 100 per cent fit after a long injury lay-off.
Lokomotiv Moscow: Guilherme; Ignatyev, Höwedes, Murilo, Corluka, Rybus; Krychowiak, Barinov, Joao Mario; Al Miranchuk, Eder
Juventus: Szczesny; Danilo, Bonucci, Demiral, Alex Sandro; Khedira, Pjanic, Bentancur; Ramsey/Douglas Costa; Higuain, Ronaldo
Ref: Buquet (FRA)