Kick off: 21:00 (CET)
Date: Wed, 03-Oct-18
Alli has been ruled out of the welcome of Barcelona, and is joined on the sidelines by Dembele, Eriksen, Vertonghen and Aurier.
Lloris is available and could replace Gazzaniga between the sticks, while Davies, Lamela and Wanyama may all start.
Messi played a key role off the bench for Barcelona against Athletic Club on Saturday and should return to the starting XI.
Lenglet is expected to deputise for the suspended Umtiti alongside Pique at the heart of the defence.
After starting the stalemate with Athletic in midfield, Roberto will miss out here, with Semedo set to continue at right-back.
Reports from Spain also suggest that Valverde will revert to a 4-4-2 setup, with Dembele dropped, which could see Vidal start in midfield and Rakitic moved to the right.
Tottenham were pegged back by Inter to lose 2-1 late on in their group stage opener. However, since that loss, Tottenham have won their last three and will hope to continue that good form with the welcome of Barcelona.
Barcelona, meanwhile, have endured a downturn in form having failed to win their last three, drawing two. A 2-1 loss at Leganes shows that the Blaugrana are beatable, but they can dominate any opponent on their day and a repeat of their 4-0 win over PSV would certainly go down well with their fans.
The hosts are in form, but could be without two key men, and while Barcelona look out of sorts, an entertaining draw could be on the cards at Wembley on Wednesday night.
Tottenham 2-2 Barcelona