Chelsea face Barcelona at Camp Nou after a 1-1 draw at Stamford Bridge.
Fabregas said: “If I am lucky enough to play, it’s true that we are positioned in nearby areas of the pitch, stopping him will be difficult but I will try to do everything possible so that he feels uncomfortable and can’t put together a perfect performance.
“I see Messi as a rival who wants to win, and I want the same thing. We are in different teams and each player wants what is best for their own club. Obviously, you always have respect for each other.
“I don’t mind playing against my past, against my friends. I like it, the feelings have always been positive ones. I did it with Arsenal and now with Chelsea, I’ve felt pretty good on both occasions.
“It doesn’t bother me to play against my previous club or old friends, it motivates me. As I said I am really motivated I want nobody to doubt that I want the best for my current club. In fact, it gives me extra motivation.”